Homology
This web page was produced as an assignment for Genetics 564, an undergraduate capstone course at UW-Madison.
Homology between organisms indicates a common ancestor in their evolutionary path that contained a specific gene. Organisms are considered homologs when they share a similar sequence that encodes a gene. There are two kinds of homologs, orthologs and paralogs. Orthologs are species that have differentially evolved in a way that the normal function of gene is maintained while the sequence of the gene may be altered [1]. In this case, the gene of interest remains on the same locus in genome. Paralogs are organisms that have a similar gene sequence in a different location in the genome. This occurs when there is a duplication of the gene during DNA synthesis [2].
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Homologs of VHL
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Drosophila melanogaster (Fruit Fly)
VHL tumor suppressor Accession #: AAF29377 Length: 178 a.a 28.4% Identity |
References
1.“Homologs, Orthologs, and Paralogs.” Boundless Microbiology Boundless, 10 Nov. 2016. Retrieved 14 Feb. 2017 from https://www.boundless.com/microbiology/textbooks/boundless-microbiology-textbook/microbial-genetics-7/bioinformatics-83/homologs-orthologs-and-paralogs-456-8410/
2. Griffiths, Anthony J. F. "Genomes and Genomics." Introduction to Genetic Analysis. New York: W.H. Freeman, 2015. 528. Print.
1.“Homologs, Orthologs, and Paralogs.” Boundless Microbiology Boundless, 10 Nov. 2016. Retrieved 14 Feb. 2017 from https://www.boundless.com/microbiology/textbooks/boundless-microbiology-textbook/microbial-genetics-7/bioinformatics-83/homologs-orthologs-and-paralogs-456-8410/
2. Griffiths, Anthony J. F. "Genomes and Genomics." Introduction to Genetic Analysis. New York: W.H. Freeman, 2015. 528. Print.